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sjfst 2026, 8(2): 1-9 |
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Alijaniha M, Alijaniha M, Mirzaalimohammadi M. Development of Eugenol-Embedded Chitosan-Mesoporous Silica Nanoparticle Antimicrobial Coatings for Biofilm Control on Medical Devices. sjfst 2026; 8 (2) :1-9
URL: http://sjfst.srpub.org/article-6-274-en.html
URL: http://sjfst.srpub.org/article-6-274-en.html
1- Zanjan University of Medical Sciences, Iran , m.gerami@itrc.ac.ir
2- Tabriz University of Medical Sciences, Iran
3- Semnan Azad University, Iran
2- Tabriz University of Medical Sciences, Iran
3- Semnan Azad University, Iran
Abstract: (9 Views)
This study aims to develop an antimicrobial coating using eugenol, an essential oil component, incorporated into chitosan and mesoporous silica nanoparticles (MSNs) to inhibit biofilm formation on medical devices. MSNs were synthesized using the Stöber method [1], loaded with eugenol, and embedded into a crosslinked chitosan coating. The coatings were characterized using techniques such as SEM, FTIR, and XPS. Eugenol release was evaluated under different pH conditions. Antimicrobial and antibiofilm activities were tested against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Pseudomonas aeruginosa using growth inhibition assays, Live/Dead staining, and SEM. Biocompatibility was assessed with NIH/3T3 fibroblasts. The eugenol-loaded coating demonstrated controlled release, with increased release at pH 6 compared to pH 7.4. It significantly reduced planktonic growth and biofilm formation of all tested bacteria, killing >94% of adherent cells. The chitosan coating alone showed limited antimicrobial activity. The eugenol-containing coating was biocompatible in indirect contact but slightly reduced cell metabolic activity in direct contact. The eugenol-releasing chitosan-MSN coating effectively inhibits biofilm formation and demonstrates potential as an antimicrobial surface for medical devices. Incorporating antimicrobial agents like eugenol is essential for optimal antibiofilm activity. This work provides a foundation for developing chitosan-based coatings with other essential oils or antibiotic alternatives.
Keywords: Antimicrobial coatings, essential oils, biofilm control, eugenol, chitosan, mesoporous silica nanoparticles (MSNs)
Type of Study: Research |
Subject:
Surfaces, Coatings and Films
Received: 2026/02/15 | Revised: 2026/04/20 | Accepted: 2026/06/9 | Published: 2026/06/25
Received: 2026/02/15 | Revised: 2026/04/20 | Accepted: 2026/06/9 | Published: 2026/06/25
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