دوره 2، شماره 1 - ( 11-1398 )                   جلد 2 شماره 1 صفحات 13-1 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rezaei E. Level of Expression of BDNF and TNF-Alpha in the Somatosensory Cortex and its Effect on Social Interaction in Autism Model Rats Induced by Valproic Acid. sjfst. 2020; 2 (1) :1-13
URL: http://sjfst.srpub.org/article-6-46-fa.html
رضایی الهه. بررسی سطح بیان BDNF و TNF-Alpha در قشر حسی مغز در اثر القای اسید والپروئیک و تأثیر آن بر تعامل اجتماعی در موشهای صحرایی مدل اوتیسم. تحقیقات بنیادی علوم و تکنولوژی. 1398; 2 (1) :13-1

URL: http://sjfst.srpub.org/article-6-46-fa.html


دکترای زیست شناسی جانوری
چکیده:   (825 مشاهده)
مطالعات نشان داده است که قرار گرفتن در معرض اسید والپروئیک (VPA) در دوران بارداری ممکن است منجر به "سندرم والپروات جنین" شود که دارای خصوصیاتی شبیه به اوتیسم است. هدف از این مطالعه بررسی سطح بیان فاکتور نوروتروفیک مشتق شده از مغز، فاکتور نکروز تومور آلفا و تأثیر این عوامل بر قشر مغز در موشهای صحرایی مدل اوتیسم با ااستفاده از اثر القایی اسید والپروئیک در دوره قبل از تولد و همچنین عملکردهای اجتماعی و اختلالات رفتاری مرتبط با مدلهای حیوانی اوتیسم در موشها است. در اواسط روز دوازدهم بارداری (ED 12.5)  ، میران 500 میلی گرم اسید والپروئیک (VPA ، SIGMA) محلول در بافر فسفات (PBS) به صورت داخل صفاقی به موشهای ماده در گروه آزمایش تزریق شد (10 =n). 30 و 60 روز پس از تولد ، برای ارزیابی رفتار اجتماعی و  تعامل اجتماعی ، آزمون های میدان باز و آزمایش های Y-Maze انجام شد. سپس، سطح بیان BDNF و TNF-α قشر حسی مغز با روش ELISA  در سرم اندازه گیری شد. نتایج این آزمایشات نشان داد که  در موشهای صحرایی مدل اوتیسم در اثر القای اسید والپروئیک ، ارتباطات اجتماعی ضعیفی وجود دارد و به دنبال آن کاهش و افزایش سیتوکینهایی مانند BDNF و TNF-alpha در قشر حسی و سرم خون موشها مشاهده گردید. چنین تجزیه و تحلیل هایی حداقل در مدل های حیوانی راهی برای شناخت اختلال اجتماعی ناشی از اوتیسم است.
متن کامل [PDF 748 kb]   (304 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: ژنتیک
دریافت: 1398/7/16 | پذیرش: 1398/10/4 | انتشار: 1398/11/11

فهرست منابع
1. Gericke, Arne. Munson, Mary. and Ross, Alonzo H. (2006).Regulation of the PTEN phosphatase. Gene. Vol. 374. 1-9. [DOI:10.1016/j.gene.2006.02.024] [PMID]
2. Willemsen‐Swinkels, SH. Bakermans‐Kranenburg, MJ. Buitelaar, JK. IJzendoorn, MH.Van. and Engeland, H.Van. (2000).Insecure and disorganised attachment in children with a pervasive developmental disorder: Relationship with social interaction and heart rate. Journal of Child Psychology and Psychiatry. Vol. 41. No. 6. 759-767. [DOI:10.1111/1469-7610.00663] [PMID]
3. Iwata, Keiko. Matsuzaki, Hideo. Takei, Nori. Manabe, Takayuki. and Mori, Norio. (2010).Animal models of autism: an epigenetic and environmental viewpoint. Jornal of Central Nervous System Disease. (2010). 2. 37-44. [DOI:10.4137/JCNSD.S6188] [PMID] [PMCID]
4. Markram, Henry. Rinaldi, Tania. Markram, Kamlia. (2007).The Intense World Syndrome - an Alternative Hypothesis for Autism. Frontier in Neuroscience. Vol. 1(1). 77-96. [DOI:10.3389/neuro.01.1.1.006.2007] [PMID] [PMCID]
5. Duch, Wlodzislaw. Nowak, Wieslaw. Meller, Jaroslw. Osinski, Grzegorz. Dobosz, Krzysztof. Mikotajewski, Dariusz. and Wojcik Grzegorz.M. (2012).Computational approach to underestanding autism spectrum disorders. Computer Science. Vol. 13(2). 47-61. [DOI:10.7494/csci.2012.13.2.47]
6. Lynch, Charles.J. Uddin, Lucina.Q. Supekar, Kaustubh. Khouzam, Amirah. Phillips, Jennifer. and Menon, Vinod. (2013).Default mode network in childhood autism: Posteromedial cortex heterogeneity and relationship with social deficits. Biological Psychiatry. Vol. 74(3). 212-219. [DOI:10.1016/j.biopsych.2012.12.013]
7. Halladay, Alycia.K. Amaral, David. Aschner, Michael. Bolivar, Valerie.J. Bowman, A. DiCicco-Bloom, Emanuel. Hyman, Susan.L. Keller, Flavio. Lein, Pamela. Pessah, Isaac. Restifo, Linda. and Threadgill, David.W. (2009).Animal models of autism spectrum disorders: information for neurotoxicologists. Neurotoxicology. Vol. 30(5). 811-821. [DOI:10.1016/j.neuro.2009.07.002] [PMID] [PMCID]
8. Rinaldi, Tania. Silberberg, Gilda. and Markram, Henry. (2008).Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid. Cerebral cortex. Vol. 18(4). 763-770. [DOI:10.1093/cercor/bhm117] [PMID]
9. Reynard, Janine. (2011). The impact of environmental enrichment on neurogenesis in an animal model of Autism. Doctoral dissertation, University of Manitoba.
10. Kim, Soo-Jeong. Silva, Raquel.M. Flores, Cindi.G. Jacob, Suma. Guter, Stephen. Valcante, Gregory. Annette, M.Zaytoun. Edwin.H, Cook. and Badner.A, Judith. (2011).A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders. Molecular Autism. Vol. 2(1). 8. [DOI:10.1186/2040-2392-2-8] [PMID] [PMCID]
11. Bambini-Junior, Victorio. Rodrigues, Leticia. Behr, Guilherme.Antonio. Fonseca, Moreira, Jose Claudio Fonseca. Riesgo, Rudimar. Gottfried, Carmem. (2011).Animal model of autism induced by prenatal exposure to valproate: Behavioral changes and liver parameters. Brain Research. Vol. 1408. 8-16. [DOI:10.1016/j.brainres.2011.06.015] [PMID]
12. Damke, Edilson. Storti-Filho, Agenor. Irie, Mary.M.T. Carrara, Marcia.A. Batista, Marcia.R. Donatti, Lucelia. Gunther, Luciene.S.A. Patussi, Eliana.V. Svidzinski, Terezinha.I.E. and Consolaro, Marcia.E.L. (2010).Ultrastructural Imaging of Candida albicans Adhesion to Rat Genital Epithelium through Scanning and Transmission Electron Microscopy. Microscopy Microanalysis. Vol. 16(3). 337-345. [DOI:10.1017/S1431927610000164] [PMID]
13. Olexova, Lucia. Senko, Tomas. Štefanik, Peter. Talarovicova, Alzbeta. and Krskova Lucia. (2013).Habituation of exploratory behaviour in VPA rats: animal model of autism. Interdiscip Toxicol. Vol. 6(4). 222-227. [DOI:10.2478/intox-2013-0033] [PMID] [PMCID]
14. Schneider, Tomasz, Turczak, Joanna. and Przewłocki, Ryszard. (2006).Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism. Neuropsychopharmacology. Vol. 31. 36-46. [DOI:10.1038/sj.npp.1300767]
15. Markram, Kamila. Rinaldi, Tania. Mendola, Deborah.La. Sandi, Carmen. and Markram, Henry. (2008).Abnormal Fear Conditioning and Amygdala Processing in an Animal Model of Autism. Neuropsychopharmacology. Vol. 33. 901-912. [DOI:10.1038/sj.npp.1301453] [PMID]
16. Narita, Masaaki. Oyabu, Akiko. Imura, Yoshi. Kamada, Naoki. Yokoyama, Tomomi. Tano, Kaori. Uchida, Atsuko. and Narita, Naoko. (2010).Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. Neuroscience Research. Vol. 66. 2-6. [DOI:10.1016/j.neures.2009.09.001]
17. Tamburella, Alessandra. Micale, Vincenzo. Mazzola, Carmen. Salomone, Sslvatore. and Drago, Filippo. (2012).The selective norepinephrine reuptake inhibitor atomoxetine counteracts behavioral impairments in trimethyltin-intoxicated rats. European Journal of Pharmacology. Vol. 683. 148-154. [DOI:10.1016/j.ejphar.2012.02.045] [PMID]
18. Schneider, Cindy K. Melmed, Raun D. Barstow, Leon E. Enriquez F.Javir. Ranger-Moore, James. and Ostrem James A. (2006).Oral human immunoglobulin for children with autism and gastrointestinal dysfunction: a prospective, open-label study. Journal of Autism Developmental Disorders. Vol. 36. 1053-1064. [DOI:10.1007/s10803-006-0141-y] [PMID]
19. Wagner, George C. Reuhl, Kenneth R. Cheh, Michelle. McRae, Paulette. and Halladay, Alycia K. (2006). A new neurobehavioral model of autism in mice: pre-and postnatal exposure to sodium valproate. Journal of Autism Developmental Disorders. Vol. 36. 779-793. [DOI:10.1007/s10803-006-0117-y] [PMID]
20. Silverman, Jill L. Tolu, Seda S. Barkan, Charlotte L. Crawley, Jacqueline N. (2010).Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP. Neuropsychopharmacology. Vol. 35. 976-989. [DOI:10.1038/npp.2009.201] [PMID] [PMCID]
21. Ghasemi T, Abnous K, Vahdati F, Mehri S, Razavi BM, Hosseinzadeh H. (2014). Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus. Drug Res. 233: 132-55. [DOI:10.1055/s-0034-1371876] [PMID]
22. Bauman, Margaret L and Kemper, Thomas L. (2005). Neuroanatomic observations of the brain in autism: A review and future directions. International journal of developmental Neuroscience. Vol. 23. 183-187. [DOI:10.1016/j.ijdevneu.2004.09.006] [PMID]
23. Damke, Edilson. Storti-Filho, Agenor. Irie, Mary M.T. Carrara, Marcia A. Batista, Marcia R. Donatti, Lucelia. Gunther, Luciene S.A. Patussi, Eliana V. Svidzinski, Terezinha I.V. and Consolaro, Marcia E.L. (2010). Ultrastructural Imaging of Candida albicans Adhesion to Rat Genital Epithelium through Scanning and Transmission Electron Microscopy. Microscopy Microanalysis. Vol 16. 337-345. [DOI:10.1017/S1431927610000164] [PMID]
24. Karege, Felicien. Schwald, Michele. and Cisse, Mbaye. (2002).Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neuroscience letters. Vol. 328. 261-264. [DOI:10.1016/S0304-3940(02)00529-3]
25. Lynch, Charles J. Uddin, Lucina Q. Supekar, Kaustubh. Khouzam, Amirah. Phillips, Jennifer. and Menon, Vinod. (2013).Default mode network in childhood autism: Posteromedial cortex heterogeneity and relationship with social deficits. Biological Psychiatry. Vol. 74. 212-219. [DOI:10.1016/j.biopsych.2012.12.013]
26. MacFabe, Derrick F. Rodríguez-Capote, Karina. Hoffman, Jennifer E. Franklin, Andrew E. Mohammad-Asef, Yalda. Taylor, A.Roy. Boon, Francis. Cain, Donald P. Kavaliers, Martin. Possmayer, Fred. and Ossenkopp, Klaus-Peter. (2008).A Novel Rodent Model of Autism: Intraventricular Infusions of Propionic Acid Increase Locomotor Activity and Induce Neuroinflammation and Oxidative Stress in Discrete Regions of Adult Rat Brain. American Journal of Biochemistry and Biotechnology. Vol. 4. 146-166. [DOI:10.3844/ajbbsp.2008.146.166]
27. Pardo, Carlos A. Vargas, Diana L. Zimmerman, Andrew W. (2005). Immunity, neuroglia and neuroinflammation in autism. International Review Psychiatry. Vol. 17. 485-495. [DOI:10.1080/02646830500381930] [PMID]
28. Schumann, Cynthia Mills. And Nordahl, Christine Wu Nordahl. (2011). Bridging the gap between MRI and postmortem research in autism. Brain Research. Vol. 1380. 175-186. [DOI:10.1016/j.brainres.2010.09.061] [PMID] [PMCID]
29. Schneider, Tomasz. and Przewłocki, Ryszard. (2005). Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism. Neuropsychopharmacology. Vol. 30. 80-89. [DOI:10.1038/sj.npp.1300518]
30. Sokhadze, Estate M. Frederick, Jon. Yao, Wang. Maiying, Kong. El-Baz, Ayman. Tasman, Allan. and Casanova, Manuel F. (2015). Event-related potential studies of cognitive processing abnormalities in autism. Imag Brain Autism. Vol. 7. 391-412.
31. Tarkowski, Elisabeth. Blennow Kaj. Wallin, Anders. and Tarkowski, Andrzej. (1999). Intracerebral production of tumor necrosis factor-α, a local neuroprotective agent, in alzheimer disease and vascular dementia. Journal of Clinical Immunology. Vol. 19. 223-230. [DOI:10.1023/A:1020568013953] [PMID]
32. Tetreault, Nicol A. Hakeem, Atiya Y. Jiang, Sue. Williams, Brine A. Allman, Elizabeth. Wold, Barbara J. and Allman, John M. (2012). Microglia in the cerebral cortex in autism. Journal of Autism and Developmental Disorders. Vol. 42. 2569-2584. [DOI:10.1007/s10803-012-1513-0] [PMID]
33. Mansour, Mona. Mohamed, Afaf. Azam, Hanan. and Henedy, Mohsen. (2010). Brain derived neurotrophic factor in autism. Curent Psychiatry. Vol. 17. No. 1. 23-29.
34. Belmonte, Matthew K. and Bourgeron, Thomas. (2006). Fragile X syndrome and autism at the intersection of genetic and neural networks. Nature Neuroscience. Vol. 9. 1221-1225. [DOI:10.1038/nn1765] [PMID]
35. Iarocci, Grace. And McDonald, John. (2006). Sensory Integration and the Perceptual Experience of Persons with Autism. Journal of Autism and Developmental Disorders. Vol. 36. No. 1. 77-90. [DOI:10.1007/s10803-005-0044-3]
36. Bertone, Armando. Mottron, Laurent. Jelenic, Patricia. And Faubert, Jocelyn. (2005). Enhanced and diminished visuo-spatial information processing in autism depends on stimulus complexity. Brain A Journal of Neurology. Vol. 128. 2430-2441. [DOI:10.1093/brain/awh561] [PMID]
37. Volker, Martin A. Lopata, Christopher. Vujnovic, Rebecca K. Smerbeck, Audrey M. Toomey, Jennifer A. Rodgers, Jonathan D. Schiavo, Audrey and Thomeer, Marcus L. (2009).Comparison of the Bender Gestalt-II and VMI-V in Samples of Typical Children and Children With High-Functioning Autism Spectrum Disorders. Journal of Psychoeducational Assessment. Vol. 33. [DOI:10.1177/0734282909348216]
38. Yip, Jane. Soghomonian, Jean-Jacques. and Blatt, Gene J. (2007).Increased GAD67 mRNA expression in cerebellar interneurons in autism: Implications for Purkinje cell dysfunction. Journal of Neuroscience Research. Vol. 86. No. 3. 525-530. [DOI:10.1002/jnr.21520] [PMID]
39. Ricci, S. Businaro, R. Ippoliti, F. Vasco, V. R. Lo. Massoni, F. Onofri, F. Troili, G. M. Pontecorvi, V. Morelli, M. Rapp Ricciardi, M. Archer, T. (2013). Altered Cytokine and BDNF Levels in Autism Spectrum Disorder. Neurotoxicity Research. Vol. 24. 491-501. [DOI:10.1007/s12640-013-9393-4] [PMID]
40. Peterson, Candida C. Wellman, Henry M. and Liu, David. (2005).Steps in Theory-of-Mind Development for Children With Deafness or Autism. Child Development. Vol. 76. No. 2. 502-517. [DOI:10.1111/j.1467-8624.2005.00859.x] [PMID]
41. Hashimoto, Kenji. Iwata, Yasuhide. Nakamura, Kazuhiko. Tsujii, Masatsugu. Tsuchiya, Kenji J. Sekine, Yoshimoto. Suzuki, Katsuaki. Minabe, Yoshio. Takei, Nori. Iyo, Masaomi. Mori, Norio. (2006). Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Vol. 30. No. 8. 1529-1531. [DOI:10.1016/j.pnpbp.2006.06.018]
42. Miyazaki, Kaoru. Narita, Naoko and Narita, Masaaki. (2005).Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: implication for pathogenesis of autism. International Journal of Developmental Neuroscience. Vol. 23. No. 2-3. 287-297. [DOI:10.1016/j.ijdevneu.2004.05.004] [PMID]

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

ارسال پیام به نویسنده مسئول


بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.